Neuronal ASIC1A As a Cerebral pH Sensor
نویسندگان
چکیده
منابع مشابه
Photonic porous silicon as a pH sensor
Chronic wounds do not heal within 3 months, and during the lengthy healing process, the wound is invariably exposed to bacteria, which can colonize the wound bed and form biofilms. This alters the wound metabolism and brings about a change of pH. In this work, porous silicon photonic films were coated with the pH-responsive polymer poly(2-diethylaminoethyl acrylate). We demonstrated that the pH...
متن کاملPotent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.
Stroke is the second-leading cause of death worldwide, yet there are no drugs available to protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in mammalian brain and a key mediator of acidosis-induced neuronal damage following cerebral ischemia. Genetic ablation and selective pharmacologic inhibition of ASIC1a reduces neuronal d...
متن کاملOptical pH Sensor Based on Quinizarin for Alkaline pH Regions
The development of an optical pH sensor based on immobilization of quinizarin (1,4-dihydroxyanthraquinone) on a triacetylcellulose membrane was described. The resulting membrane exhibited fast color change from yellow to violet, while changing the pH in alkaline region. The immobilized quinizarin showed a broader dynamic range from (pH 9.4-11.4) with respect to free form (pH 8.8-10.4). The sens...
متن کاملIon-sensitive field effect transistor as a pH sensor.
In this work, both the static and dynamic behaviors as well as the signal read-out circuits of ISFETs were studied. The standard NMOS structure in conjunction with the insulator-electrolyte capacitor was used to model the ISFET under study. The site-binding theory was incorporated to describe the chemistry occurring at the insulator/electrolyte interface. The mechanism of the threshold voltage ...
متن کاملA combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.
Acid-sensing ion channels (ASICs) are key receptors for extracellular protons. These neuronal nonvoltage-gated Na(+) channels are involved in learning, the expression of fear, neurodegeneration after ischemia, and pain sensation. We have applied a systematic approach to identify potential pH sensors in ASIC1a and to elucidate the mechanisms by which pH variations govern ASIC gating. We first ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2019
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.119.315925